PBIT
Cat. No.：YN310041
CAS No. ：2514-30-9
规格
价格(RMB)
库存
| 产品名称: | PBIT |
| CAS No.: | 2514-30-9 |
| Chemical Name: | 2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one |
| Synonyms: | Jumonji HDM Inhibitor |
| 分子量: | 241.31 |
| 分子式: | C₁₄H₁₁NOS |
| SMILES: | O=C1N(C2=CC=C(C)C=C2)SC3=C1C=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PBIT 是一种特异性的 Jumonji/AT 富集互作结构域 1 (JARID1) 抑制剂。PBIT 抑制JARID1B(KDM5B或PLU1) 组蛋白去甲基化酶，IC50值约为 3 μM。 PBIT 还抑制JARID1A和JARID1C，IC50分别为 6 μM 和 4.9 μM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Sayegh, J., Cao, J., Zou, M.R., et al.Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screenJ. Biol. Chem.288(13),9408-9417(2013)
