GSK2879552
Cat. No.：YN310305
CAS No. ：1401966-69-5
| 产品名称: | GSK2879552 |
| CAS No.: | 1401966-69-5 |
| Chemical Name: | 4-[[4-[[[(1R,2S)-2-phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]-benzoic acid |
| Synonyms: | GSK2879552 2HCl |
| 分子量: | 364.48 |
| 分子式: | C₂₃H₂₈N₂O₂ |
| SMILES: | O=C(O)C1=CC=C(CN2CCC(CN[C@H]3[C@H](C4=CC=CC=C4)C3)CC2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK2879552 是一种可口服的，不可逆的LSD1/ KDM1A抑制剂，具有抗肿瘤活性。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Mohammad, H.P., Smitheman, K.N., Kamat, C.D., et al.A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLCCancer Cell28(1),57-69(2015)
Maes, T., Mascaró, C., Ortega, A., et al.KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative diseaseEpigenomics7(4),609-626(2015)
Zheng, Y.C., Yu, B., Jiang, G.Z., et al.Irreversible LSD1 inhibitors: Application of tranylcypromine and its derivatives in cancer treatmentCurr. Top. Med. Chem.16(19),2179-2188(2016)
