KDM4D-IN-1
Cat. No.：YN310051
CAS No. ：2098902-68-0
| 产品名称: | KDM4D-IN-1 |
| CAS No.: | 2098902-68-0 |
| Chemical Name: | 4,5-dihydro-2-methyl-5-oxo-pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile |
| Synonyms: | KDM4D-IN-1;BCP32624;BDBM50242878;s1059 |
| 分子量: | 225.21 |
| 分子式: | C₁₁H₇N₅O |
| SMILES: | OC1=NC2=C(C#N)C(C)=NN2C3=C1C=CC=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KDM4D-IN-1 是一种新型组蛋白赖氨酸去甲基化酶 4D (KDM4D) 抑制剂，IC50为 0.41±0.03 μM。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Fang, Z., Wang, T.-q., Li, H., et al.Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitorsBioorg. Med. Chem. Lett.27(14),3201-3204(2017)
Yan, H., Zhu, L., Zhang, J., et al.Histone demethylase KDM4D inhibition suppresses renal cancer progression and angiogenesis through JAG1 signalingCell Death Discov.7(1),284(2021)
