NVS-PAK1-1
Cat. No.：YN290011
CAS No. ：1783816-74-9
| 产品名称: | NVS-PAK1-1 |
| CAS No.: | 1783816-74-9 |
| Chemical Name: | (3S)-3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-1-pyrrolidinecarboxamide |
| Synonyms: | NVS-PAK1-1，NVS-PAK11，NVS-PAK1 1 |
| 分子量: | 479.93 |
| 分子式: | C₂₃H₂₅ClF₃N₅O |
| SMILES: | FC1=CC2=C(C=C1)N(CC(F)F)C3=C(C=C(Cl)C=C3)C(N[C@H]4CCN(C(NC(C)C)=O)C4)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NVS-PAK1-1是有效，选择性的PAK1变构抑制剂，IC50值为5 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Karpov, A.S., Amiri, P., Bellamacina, C., et al.Optimization of a dibenzodiazepine hit to a potent and selective allosteric PAK1 inhibitorACS Med. Chem. Lett.6(7),776-781(2015)
Semenova, G., and Chernoff, J.Targeting PAK1Biochem. Soc. Trans.45(1),79-88(2017)
