GNE 2861
Cat. No.：YN290210
CAS No. ：1394121-05-1
| 产品名称: | GNE 2861 |
| CAS No.: | 1394121-05-1 |
| Chemical Name: | 1-[2-[1-(2-amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]-cyclohexanol |
| Synonyms: | GNE2861 |
| 分子量: | 406.48 |
| 分子式: | C₂₂H₂₆N₆O₂ |
| SMILES: | OC1(C#CC2=CC=C3N=C(NCCOC)N(C4=NC(N)=NC=C4)C3=C2)CCCCC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNE 2861 是PAK的抑制剂，对 group II 具有选择性。GNE 2861 抑制 PAK4，PAK5 和 PAK6 的IC50值分别为7.5，36和126 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Staben, S.T., Feng, J.A., Lyle, K., et al.Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitorsJ. Med. Chem.57(3),1033-1045(2014)
Zhuang, T., Zhu, J., Li, Z., et al.p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cellsOncotarget6(41),43853-43868(2015)
