FRAX597
Cat. No.：YN290350
CAS No. ：1286739-19-2
| 产品名称: | FRAX597 |
| CAS No.: | 1286739-19-2 |
| Chemical Name: | 6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Synonyms: | FRAX597;6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one;6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one,hydrochloride; |
| 分子量: | 558.10 |
| 分子式: | C₂₉H₂₈ClN₇OS |
| SMILES: | O=C1C(C2=CC=C(C3=CN=CS3)C=C2Cl)=CC4=CN=C(NC5=CC=C(N6CCN(C)CC6)C=C5)N=C4N1CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FRAX597 是一种有效的 I型 P21激活激酶 (PAK)抑制剂，作用于PAK1，2和3，IC50分别为 8，13 和 19 nM。 |
| IC50和靶点: | [{name:"PAK1:8 nM (IC50)"},{name: "PAK2:13 nM (IC50)"},{name: "PAK3:19 nM (IC50)"}] |
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Licciulli, S., Maksimoska, J., Zhou, C., et al.FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated SchwannomasJ. Biol. Chem.288(40),29105-29114(2013)
Yeo, D., He, H., Patel, O., et al.FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabineBMC Cancer16,24(2016)
Prudnikova, T.Y., Villmar-Cruz, O., Rawat, S.J., et al.Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cellsOncogene35(17),2178-2185(2016)
Yeo, D., Phillips, P., Baldwin, G.S., et al.Inhibition of group 1 p21-activated kinases suppresses pancreatic stellate cell activation and increases survival of mice with pancreatic cancerInt. J. Cancer140(9),2101-2111(2017)
