FRAX1036
Cat. No.：YN290458
CAS No. ：1432908-05-8
| 产品名称: | FRAX1036 |
| CAS No.: | 1432908-05-8 |
| Chemical Name: | 6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Synonyms: | |
| 分子量: | 518.05 |
| 分子式: | C₂₈H₃₂ClN₇O |
| SMILES: | O=C1C(C2=CC=C(C3=NC(C)=CN=C3)C=C2Cl)=CC4=CN=C(NCCC5CCN(C)CC5)N=C4N1CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FRAX1036 是一种PAK抑制剂，对 PAK1，PAK2 和 PAK4 的Ki值分别为 23.3 nM，72.4 nM 和 2.4 μM。 |
| IC50和靶点: | [{name:"PAK1:23.3 nM (Ki)"},{name: "PAK2:72.4 nM (Ki)"},{name: "PAK4:2.4 μM (Ki)"}] |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ong, C.C., Gierke, S., Pitt, C., et al.Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agentsBreast Cancer Res.17:59,(2015)
Mortazavi, F., Lu, J., Phan, R., et al.Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesisBMC Cancer15(381),(2015)
