FRAX486
Cat. No.：YN290351
CAS No. ：1232030-35-1
规格
价格(RMB)
库存
| 产品名称: | FRAX486 |
| CAS No.: | 1232030-35-1 |
| Chemical Name: | 6-(2,4-dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Synonyms: | FRAX597;6-(2,4-Dichlorophenyl)-8-ethyl-2-{[3-fluoro-4-(1-piperazinyl)phen yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one;FRAX 486;FRAX-486;Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]aMino]-;6-(2,4-Dich |
| 分子量: | 513.39 |
| 分子式: | C₂₅H₂₃Cl₂FN₆O |
| SMILES: | FC1=CC(NC2=NC=C3C(N(CC)C(C(C4=CC=C(Cl)C=C4Cl)=C3)=O)=N2)=CC=C1N5CCNCC5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FRAX486 是一种PAK抑制剂，对 PAK1，PAK2 和 PAK3 的IC50值分别为 14，33 和 39 nM。 |
| IC50和靶点: | [{name:"PAK1:14 nM (IC50)"},{name: "PAK2:33 nM (IC50)"},{name: "PAK3:39 nM (IC50)"}] |
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Dolan, B.M., Duron, S.G., Campbell, D.A., et al.Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486Proc. Natl. Acad. Sci. USA110(14),5671-5676(2013)
Hayashi-Takagi, A., Araki, Y., Nakamura, M., et al.PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescenceProc. Natl. Acad. Sci. USA111(17),6461-6466(2014)
