IPA-3
Cat. No.:YN290361
CAS No. :42521-82-4
产品名称: | IPA-3 |
CAS No.: | 42521-82-4 |
Chemical Name: | 1,1'-dithiobis-2-naphthalenol |
Synonyms: | IPA 3,IPA3 |
分子量: | 350.45 |
分子式: | C₂₀H₁₄O₂S₂ |
SMILES: | OC1=CC=C2C=CC=CC2=C1SSC3=C4C=CC=CC4=CC=C3O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | IPA-3 是一种选择性的,ATP 非竞争的PAK1抑制剂,IC50值为 2.5 μM,对 PAKs 4-6 没有抑制作用。 |
IC50和靶点: | [{name:"PAK1:2.5 μM (IC50)"}] |
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In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
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Deacon, S.W., Beeser, A., Fukui, J.A., et al.An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinaseChem. Biol.15(4),322-331(2008)
Viaud, J., and Peterson, J.R.An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalentlyMol. Cancer Ther.8(9),2559-2565(2009)