HhAntag
Cat. No.：YN450097
CAS No. ：496794-70-8
规格
价格(RMB)
库存
| 产品名称: | HhAntag |
| CAS No.: | 496794-70-8 |
| Chemical Name: | N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxy-benzamide |
| Synonyms: | N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide;HhAntag;CS-1233;GLI1-mediated transcription inhibitor |
| 分子量: | 450.92 |
| 分子式: | C₂₄H₂₃ClN₄O₃ |
| SMILES: | O=C(NC1=CC=C(Cl)C(C2=NC3=CC=C(N(C)C)C=C3N2)=C1)C4=CC(OC)=CC(OC)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HhAntag 是一种特异性、强效、具有口服活性的 Hh 通路的SMO拮抗剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Romer, J.T., Kimura, H., Magdaleno, S., et al.Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/-p53-/- miceCancer Cell6(3),229-240(2004)
Mundy, C., Bello, A., Sgariglia, F., et al.HhAntag, a hedgehog signaling antagonist, suppresses chondrogenesis and modulates canonical and non-canonical BMP signalingJ. Cell Physiol.231(5),1033-1044(2016)
