Glasdegib
Cat. No.：YN450115
CAS No. ：1095173-27-5
规格
价格(RMB)
库存
| 产品名称: | Glasdegib |
| CAS No.: | 1095173-27-5 |
| Chemical Name: | N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)-urea |
| Synonyms: | PF-04449913 |
| 分子量: | 374.44 |
| 分子式: | C₂₁H₂₂N₆O |
| SMILES: | O=C(NC1=CC=C(C#N)C=C1)N[C@H]2C[C@H](C3=NC4=CC=CC=C4N3)N(C)CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Glasdegib (PF-04449913) 是一种有效的，具有口服活性的smoothened抑制剂。Glasdegib (PF-04449913) 结合到人SMO(181-787氨基酸位点)，IC50为 4 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Munchhof, M.J., Li, Q., Shavnya, A., et al.Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothenedACS Med. Chem. Lett.3(2),106-111(2011)
Fukushima, N., Minami, Y., Kakiuchi, S., et al.Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cellsCancer Sci.107(10),1422-1429(2016)
Giordani, G., Barraco, M., Giangrande, A., et al.The human smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cellsOncotarget7(34),55313-55327(2016)
