DY131
Cat. No.：YN450100
CAS No. ：95167-41-2
规格
价格(RMB)
库存
| 产品名称: | DY131 |
| CAS No.: | 95167-41-2 |
| Chemical Name: | 4-hydroxy-benzoic acid 2-[[4-(diethylamino)phenyl]methylene]hydrazide |
| Synonyms: | GSK 9089 |
| 分子量: | 311.38 |
| 分子式: | C₁₈H₂₁N₃O₂ |
| SMILES: | O=C(N/N=C/C1=CC=C(N(CC)CC)C=C1)C2=CC=C(O)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DY131 (GSK 9089) 是一种有效的选择性的ERRγ和ERRβ激动剂，对 ERRα，ERα 和 ERβ 无效。DY131 还抑制Smo信号传导。 |
| IC50和靶点: | |
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Zuercher, W.J., Gaillard, S., Orband-Miller, L.A., et al.Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγJ. Med. Chem.49(9),3107-3109(2005)
Yu, D.D., and Forman, B.M.Identification of an agonist ligand for estrogen-related receptors ERRβ/γBioorg. Med. Chem. Lett.15(5),1311-1313(2005)
Yu, S., Wang, X., Ng, C.F., et al.ERRγ suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancerCancer Res.67(10),4904-4914(2007)
