EAI045
Cat. No.：YN340002
CAS No. ：1942114-09-1
| 产品名称: | EAI045 |
| CAS No.: | 1942114-09-1 |
| Chemical Name: | α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-2H-isoindole-2-acetamide |
| Synonyms: | EAI045;EAI-045;2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide;2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide;GTPL9222;BCP17698;s8242;EA1045;AK607730;2-(5-Fluoro-2-hy |
| 分子量: | 383.40 |
| 分子式: | C₁₉H₁₄FN₃O₃S |
| SMILES: | O=C(C(C1=C(O)C=CC(F)=C1)N2C(C(C=CC=C3)=C3C2)=O)NC4=NC=CS4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EAI045是突变体EGFR的第四代变构抑制剂，在10 μM ATP时抑制EGFR，EGFRL858R，EGFRT790M和 EGFRL858R/T790M的IC50值分别为1.9，0.019，0.19 和 0.002 μM。 |
| IC50和靶点: | [{name:"EGFR:1.9 μM (IC50)"},{name: "EGFRL858R:0.019 μM (IC50)"},{name: "EGFRT790M:0.19 μM (IC50)"},{name: "EGFRL858R/T790M:0.002 μM (IC50)"}] |
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| Solvent & Solubility: |
Jia, Y., Yun, C.H., Park, E., et al.Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitorsNature534(7605),129-132(2016)
