BMS-599626
Cat. No.：YN340329
| 产品名称: | BMS-599626 |
| CAS No.: | 714971-09-2 |
| Chemical Name: | N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid, (3S)-3-morpholinylmethyl ester |
| Synonyms: | AC480 |
| 分子量: | 530.5538032 |
| 分子式: | C27H27FN8O3 |
| SMILES: | CC(C(NC(OC[C@H]1NCCOC1)=O)=C2)=C3N2N=CN=C3NC4=CC=C5C(C=NN5CC6=CC(F)=CC=C6)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-599626 (AC480) 是一种选择性的口服生物利用度HER1和HER2抑制剂，其IC50分别为 20 和 30 nM。BMS-599626 对 HER4 的 IC50值为 190 nM，对 VEGFR2、c-Kit、Lck、MEK 的抑制强度降低了100倍。BMS-599626抑制肿瘤细胞增殖，并有可能增加肿瘤对放疗的反应。 |
| IC50和靶点: | |
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Wong, T.W., Lee, F.Y., Yu, C., et al.Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signalingClin. Cancer Res.12(20 Pt 1),6186-6193(2006)
Kedrin, D., Wyckoff, J., Boimel, P., et al.ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasationClin. Cancer Res.15(11),3733-3739(2009)
