PIM447
Cat. No.：YN340337
CAS No. ：1210608-43-7
规格
价格(RMB)
库存
| 产品名称: | PIM447 |
| CAS No.: | 1210608-43-7 |
| Chemical Name: | N-[4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide; LGH 447 |
| Synonyms: | LGH447 |
| 分子量: | 440.46 |
| 分子式: | C24H23F3N4O |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PIM447 (LGH447) 是一种有效的、口服的、选择性的泛PIM激酶抑制剂，对 PIM1、PIM2 和PIM3的Ki值分别为 6、18 和 9 pM。PIM447 具有双重抗肿瘤和骨保护作用。PIM447 诱导细胞凋亡。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Peters, T. L., et al.: Oncotarget. 7, 63362 (2016)
Bataille, C. J., et al.: Bioorg Med Chem. 25, 2657 (2017)
