Colivelin
Cat. No.：YN340332
| 产品名称: | Colivelin |
| CAS No.: | 867021-83-8 |
| Chemical Name: | L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-proline |
| Synonyms: | CLN |
| 分子量: | 2645.10362 |
| 分子式: | C119H206N32O35 |
| SMILES: | [H]N[C@@H](CO)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@]([C@H](CC)C)([H])C(N1CCC[C@H]1C(N[C@H](C(N2CCC[C@H]2C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C) |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Colivelin 是一种具有大脑通透性的神经保护肽 (neuroprotective peptide)，是STAT3的有效激活剂。Coliveli 通过激活STAT3在体外抑制神经元死亡。Colivelin 对神经毒性、Aβ 沉积,神经元细胞凋亡,在神经退行性疾病显示出长期有利的影响。Colivelin 具有潜力用于阿尔茨海默病和缺血性脑损伤的相关研究。 |
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Chiba, T., Yamada, M., Hashimoto, Y., et al.Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: Characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivoJ. Neurosci.25(44),10252-10261(2005)
Yamada, M., Chiba, T., Sasabe, J., et al.Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's diseaseNeuropsychopharmacology33(8),2020-2032(2008)
Chiba, T., Yamada, M., Sasabe, J., et al.Colivelin prolongs survival of an ALS model mouseBiochem. Biophys. Res. Commun.343(3),793-798(2006)
