TX1-85-1
Cat. No.：YN340016
CAS No. ：1603845-32-4
| 产品名称: | TX1-85-1 |
| CAS No.: | 1603845-32-4 |
| Chemical Name: | N-[5-[1-[4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-phenoxyphenyl]-2-propenamide |
| Synonyms: | TX-85-1, ErbB3;TX1-85-1 |
| 分子量: | 580.68 |
| 分子式: | C₃₂H₃₆N₈O₃ |
| SMILES: | CC(N1CCN(C2CCC(N3N=C(C4=CC(NC(C=C)=O)=C(OC5=CC=CC=C5)C=C4)C6=C3N=CN=C6N)CC2)CC1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TX1-85-1 是一种不可逆的Her3 (ErbB3)抑制剂，IC50值为 23 nM。TX1-85-1 是第一个选择性Her3配体，与位于 Her3 的 ATP 结合位点的 Cys721 形成共价键。TX1-85-1诱发 Her3 蛋白部分降解，并减弱 Her3 依赖性信号传导。 |
| IC50和靶点: | [{name:"ErbB3:23 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Xie, T., Lim, S.M., Westover, K.D., et al.Pharmacological targeting of the pseudokinase Her3Nat. Chem. Biol.10(12),1006-1012(2014)
