CGP52411
Cat. No.：YN340043
CAS No. ：145915-58-8
| 产品名称: | CGP52411 |
| CAS No.: | 145915-58-8 |
| Chemical Name: | 5,6-bis(phenylamino)-1H-isoindole-1,3(2H)-dione |
| Synonyms: | DAPH |
| 分子量: | 329.35 |
| 分子式: | C₂₀H₁₅N₃O₂ |
| SMILES: | O=C1NC(C2=C1C=C(NC3=CC=CC=C3)C(NC4=CC=CC=C4)=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CGP52411 (DAPH) 是一种高选择性，有效，口服活性和 ATP 竞争性的EGFR抑制剂，IC50为 0.3 μM。CGP52411 阻止有毒的 Ca2+离子流入神经元细胞，并显着抑制和逆转与阿尔茨海默症相关的β-amyloid (Aβ42)原纤维聚集物的形成。 |
| IC50和靶点: | [{name:"EGFR:0.3 μM (IC50)'}, 'Amyloid-β'] |
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