AG-490
Cat. No.：YN340089
CAS No. ：133550-30-8
规格
价格(RMB)
库存
| 产品名称: | AG-490 |
| CAS No.: | 133550-30-8 |
| Chemical Name: | (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
| Synonyms: | Tyrphostin AG 490 |
| 分子量: | 294.30 |
| 分子式: | C₁₇H₁₄N₂O₃ |
| SMILES: | O=C(NCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2.[(E)] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AG-490是酪氨酸激酶抑制剂，其抑制EGFR，Stat-3和JAK2/3。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Gazit, A., Yaish, P., Gilon, C., et al.Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitorsJ. Med. Chem.32(10),2344-2352(1989)
Meydan, N., Grunberger, T., Dadi, H., et al.Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitorNature379(6566),645-648(1996)
Price, F.D., von Maltzahn, J., Bentzinger, C.F., et al.Inhibition of JAK-STAT signaling stimulates adult satellite cell functionNat. Med.20(10),1174-1181(2014)
