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ZM 449829

Cat. No.:YN340133

  • CAS No. :4452-06-6

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: ZM 449829
      CAS No.: 4452-06-6
      Chemical Name: 1-(2-naphthalenyl)-2-propen-1-one
      Synonyms:
      分子量:182.22
      分子式:C₁₃H₁₀O
      SMILES:C=CC(C1=CC=C2C=CC=CC2=C1)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: ZM 449829 是有效的、选择性和 ATP 竞争性的JAK3抑制剂,pIC50值为 6.8。ZM 449829 是可用于研究JAK3的药理学工具。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Brown, G.R., Bamford, A.M., Bowyer, J., et al.Naphthyl ketones: A new class of Janus kinase 3 inhibitorsBioorg. Med. Chem. Lett.10(6),575-579(2000)

      Luo, C., and Laaja, P.Inhibitors of JAKs/STATs and the kinases: A possible new cluster of drugsDrug Discov. Today9(6),268-275(2004)

      Lai, T.-S., Liu, Y., Tucker, T., et al.Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug librariesChem. Biol.15(9),969-978(2008)

      Choi, H.S., Kim, D.-A., Chung, H., et al.Screening of breast cancer stem cell inhibitors using a protein kinase inhibitor libraryCancer Cell Int.17,25(2017)

      Hussain, S.K., Broederdorf, L.J., Sharma, U.M., et al.Host kinase activity is required for Coxiella burnetii parasitophorous vacuole formationFront. Microbiol.1,137(2010)

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