WHI-P154
Cat. No.：YN340150
CAS No. ：211555-04-3
| 产品名称: | WHI-P154 |
| CAS No.: | 211555-04-3 |
| Chemical Name: | 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol |
| Synonyms: | Jak3 inhibitor ii |
| 分子量: | 376.20 |
| 分子式: | C₁₆H₁₄BrN₃O₃ |
| SMILES: | OC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WHI-P154 是一种有效的EGFR抑制剂，同时可适度的抑制JAK3的活性，IC50值分别为 4 nM 和 1.8 μM。 |
| IC50和靶点: | [{name:"EGFR:4 nM (IC50)"},{name: "JAK3:1.8 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Changelian, P.S., Moshinsky, D., Kuhn, C.F., et al.The specificity of JAK3 kinase inhibitorsBlood111(4),2155-2157(2008)
Narla, R.K., Liu, X.P., Myers, D.E., et al.4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: A novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cellsClin. Cancer Res.4(6),1405-1414(1998)
Narla, R.K., Liu, X.P., Klis, D., et al.Inhibition of human glioblastoma cell adhesion and invasion by 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3'-bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154)Clin. Cancer Res.4(10),2463-2471(1998)
Kim, Y.H., Chung, J.I., Woo, H.G., et al.Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathwayStem Cells28(10),1816-1828(2010)
