Icotinib
Cat. No.：YN340165
CAS No. ：610798-31-7
| 产品名称: | Icotinib |
| CAS No.: | 610798-31-7 |
| Chemical Name: | N-(3-ethynylphenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine |
| Synonyms: | 埃克替尼; BPI-2009 |
| 分子量: | 391.42 |
| 分子式: | C₂₂H₂₁N₃O₄ |
| SMILES: | C#CC1=CC(NC2=C(C=C(OCCOCCOCCO3)C3=C4)C4=NC=N2)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Icotinib (BPI-2009)是有效，选择性的EGFR抑制剂，IC50值为5 nM；也抑制突变型EGFRL858R，EGFRL858R/T790M，EGFRT790M和 EGFRL861Q。 |
| IC50和靶点: | [{name:"EGFR:5 nM (IC50)'}, 'EGFRL858R', 'EGFRL858R/T790M', 'EGFRT790M', 'EGFRL861Q'] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Hu, S., Xie, G., Zhang, D.X., et al.Synthesis and biological evaluation of crown ether fused quinazoline analogues as potent EGFR inhibitorsBioorg. Med. Chem. Lett.22(19),6301-6305(2012)
Yang, G., Yao, Y., Zhou, J., et al.Effects of icotinib, a novel epidermal growth factor receptor tyrosine kinase inhibitor, in EGFR-mutated non-small cell lung cancerOncol. Rep.27(6),2066-2072(2012)
