Poziotinib
Cat. No.：YN340182
CAS No. ：1092364-38-9
| 产品名称: | Poziotinib |
| CAS No.: | 1092364-38-9 |
| Chemical Name: | 1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one |
| Synonyms: | HM781-36B; NOV120101 |
| 分子量: | 491.34 |
| 分子式: | C₂₃H₂₁Cl₂FN₄O₃ |
| SMILES: | C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HM781-36B 是一种口服活性，不可逆的泛HER抑制剂。HM781-36B 抑制 EGFRwt、HER-2 和 HER-4 的IC50值分别为 3.2、5.3 和 23.5 nM，对突变的 EGFR，包括 EGFRT790M和 EGFRL858R/T790M，IC50值分别为 4.2 和 2.2 nM。具有良好的抗肿瘤活性。 |
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Cha, M.Y., Lee, K.-O., Kim, M., et al.Antitumor activity of HM781-36B, a highly effective pan-HER inhibitor in erlotinib-resistant NSCLC and other EGFR-dependent cancer modelsInt. J. Cancer130(10),2445-2454(2012)
