Butein
Cat. No.：YN340192
CAS No. ：487-52-5
| 产品名称: | Butein |
| CAS No.: | 487-52-5 |
| Chemical Name: | (2E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one |
| Synonyms: | 紫铆因; 2’,3,4,4’-tetrahydroxy Chalcone |
| 分子量: | 272.25 |
| 分子式: | C₁₅H₁₂O₅ |
| SMILES: | OC1=CC=C(C(/C=C/C2=CC(O)=C(O)C=C2)=O)C(O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Butein，可从Dalbergia odorifera T. Chen分离，是一种 cAMP 特异性的PDE抑制剂，对PDE4的IC50为 10.4 μM。Butein 是蛋白酪氨酸激酶抑制剂，对EGFR和p60c-src的IC50分别为 16 和 65 μM。Butein 通过 AKT 和 ERK/p38 MAPK 通路，靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。Butein 还是一种SIRT1激活剂 (STAC)。 |
| IC50和靶点: | [{name:"EGFR:16 μM (IC50, in HepG2 cells)"},{name: "PDE4:10.4 μM (IC50)"}] |
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