Pelitinib
Cat. No.：YN340230
CAS No. ：257933-82-7
| 产品名称: | Pelitinib |
| CAS No.: | 257933-82-7 |
| Chemical Name: | N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2E-butenamide |
| Synonyms: | 培利替尼; EKB-569; WAY-EKB 569 |
| 分子量: | 467.92 |
| 分子式: | C₂₄H₂₃ClFN₅O₂ |
| SMILES: | N#CC1=C(C2=CC(NC(/C=C/CN(C)C)=O)=C(OCC)C=C2N=C1)NC3=CC(Cl)=C(C=C3)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pelitinib (EKB-569;WAY-EKB 569) 是可逆的EGFR抑制剂，IC50值为38.5 nM。也可轻微抑制Src，MEK/ERK 和 ErbB2，IC50值分别为282，800，和1255 nM。 |
| IC50和靶点: | [{name:"EGFR:38.5 nM (IC50)"}] |
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| Solvent & Solubility: |
Arkin, M., and Moasser, M.M.HER2 directed small molecule antagonistsCurr. Opin. Investig. Drugs9(12),1264-1276(2008)
Kim, H., and Lim, H.Y.Novel EGFR-TK inhibitor EKB-569 inhibits hepatocellular carcinoma cell proliferation by AKT and MAPK pathwaysJ. Korean Med. Sci.26(12),1563-1568(2011)
