Gefitinib hydrochloride
Cat. No.：YN340241
CAS No. ：184475-55-6
| 产品名称: | Gefitinib hydrochloride |
| CAS No.: | 184475-55-6 |
| Chemical Name: | |
| Synonyms: | 盐酸吉非替尼; ZD-1839 hydrochloride |
| 分子量: | 483.36 |
| 分子式: | C₂₂H₂₅Cl₂FN₄O₃ |
| SMILES: | ClC1=C(C=CC(NC2=NC=NC3=C2C=C(C(OC)=C3)OCCCN4CCOCC4)=C1)F.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gefitinib hydrochloride (ZD1839 hydrochloride) 是一种有效，选择性和口服活性的EGFR酪氨酸激酶抑制剂，IC50为 33 nM。Gefitinib hydrochloride 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50为 54 nM)，并阻断 EGF 刺激的肿瘤细胞中EGFR自磷酸化。Gefitinib hydrochloride 还可诱导细胞自噬 (autophagy)，并具有抗肿瘤活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
