H-9 Dihydrochloride
Cat. No.：YN340297
| 产品名称: | H-9 Dihydrochloride |
| CAS No.: | 116700-36-8 |
| Chemical Name: | N-(2-aminoethyl)-5-isoquinolinesulfonamide, dihydrochloride |
| Synonyms: | |
| 分子量: | 324.2 |
| 分子式: | C11H13N3O2S • 2HCl |
| SMILES: | NCCNS(=O)(=O)c1cccc2cnccc12 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | H-9 Dihydrochloride 是一种PKA(蛋白激酶)抑制剂。H-9 Dihydrochloride (10 μM) 显著降低5-HT的兴奋性反应。H-9 Dihydrochloride 对咽部活动也有直接影响。H-9 Dihydrochloride 抑制EGF(表皮生长因子)依赖的上皮细胞系的信号转导和细胞生长。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hidaka, H., Inagaki, M., Kawamoto, S., et al.Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase CBiochemistry23,5036-5041(1984)
Papaioannou, S., Holden-Dye, L., and Walker, R.J.Evidence for a role for cyclic AMP in modulating the action of 5-HT and an excitatory neuropeptide, FLP17A, in the pharyngeal muscle of Caenorhabditis elegansInvert. Neurosci.8,91-100(2008)
Vázquez-López, A., Sierra-Paredes, G., and Sierra-Marcuño, G.Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizuresNeurochem. Res.30(5),613-618(2005)
