Oritinib
Cat. No.：YN340313
CAS No. ：2035089-28-0
| 产品名称: | Oritinib |
| CAS No.: | 2035089-28-0 |
| Chemical Name: | |
| Synonyms: | SH-1028 |
| 分子量: | 539.67 |
| 分子式: | C31H46O6 |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SH-1028 是一种不可逆的第三代EGFRTKI，可克服 T790M 介导的非小细胞肺癌耐药。SH-1028 是EGFR激酶活性的突变选择性抑制剂，抑制EGFRWT、EGFRL858R、EGFRL861Q、EGFRL858R/T790M、EGFRd746-750和EGFRd746-750/T790M激酶，IC50值分别为 18、0.7、4、0.1、1.4 和 0.89 nM。 |
| IC50和靶点: | [{name:"EGFR (WT):18 nM (IC50)"},{name: "EGFRL858R:0.7 nM (IC50)"},{name: "EGFRL861Q:4 nM (IC50)"},{name: "EGFRL858R/T790M:0.1 nM (IC50)"},{name: "EGFRd746-750:1.4 nM (IC50)"},{name: "EGFRd746-750/T790M:0.89 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
