(+)-Ochromycinone
Cat. No.：YN340322
| 产品名称: | (+)-Ochromycinone |
| CAS No.: | 28882-53-3 |
| Chemical Name: | (3S)-3,4-dihydro-8-hydroxy-3-methyl-benz[a]anthracene-1,7,12(2H)-trione |
| Synonyms: | STA-21 |
| 分子量: | 306.3 |
| 分子式: | C19H14O4 |
| SMILES: | O=C1C2=C(C=CC(C[C@H](C)C3)=C2C3=O)C(C4=C(O)C=CC=C41)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (+)-Ochromycinone 是一种天然抗生素，可有效抑制STAT3，用于癌症和银屑病的研究。 |
| IC50和靶点: | |
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Song, H., Wang, R., Wang, S., et al.A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cellsProc. Natl. Acad. Sci. USA102(13),4700-4705(2005)
Bhasin, D., Cisek, K., Pandharkar, T., et al.Design, synthesis, and studies of small molecule STAT3 inhibitorsBioorg. Med. Chem. Lett.18(1),391-395(2008)
Chen, C.L., Loy, A., Cen, L., et al.Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cellsBMC Cancer7,111(2007)
Miyoshi, K., Takaishi, M., Nakajima, K., et al.Stat3 as a therapeutic target for the treatment of psoriasis: A clinical feasibility study with STA-21, a Stat3 inhibitorJ. Invest. Dermatol.131(1),108-117(2011)
