PIM1-IN-2
Cat. No.：YN340324
| 产品名称: | PIM1-IN-2 |
| CAS No.: | 477845-12-8 |
| Chemical Name: | 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine |
| Synonyms: | |
| 分子量: | 322.8 |
| 分子式: | C17H11ClN4O |
| SMILES: | NC1=NC=CC(C2=CC3=C(C4=CC=C(Cl)C=C4)ON=C3C=C2)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PIM1-IN-2 是一种有效的 ATP 竞争性Pim-1抑制剂，其Ki为 91 nm。PIM1-IN-2 不是通过形成经典氢键来靶向 ATP 结合激酶铰链区的。 |
| IC50和靶点: | [{name:"PIM1:91 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
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Pierce, A.C., Jacobs, M., and Stuver-Moody, C.Docking study yields four novel inhibitors of the protooncogene Pim-1 kinaseJ. Med. Chem.51(6),1972-1975(2008)
Duverger, A., Wolschendorf, F., Anderson, J.C., et al.Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivationJ. Virol.88(1),364-376(2014)
Brault, L., Gasser, C., Bracher, F., et al.PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancersHaematologica95(6),1004-1015(2010)
