Pazopanib
Cat. No.：YN440062
CAS No. ：444731-52-6
规格
价格(RMB)
库存
| 产品名称: | Pazopanib |
| CAS No.: | 444731-52-6 |
| Chemical Name: | 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide |
| Synonyms: | 帕唑帕尼; GW786034 |
| 分子量: | 437.52 |
| 分子式: | C₂₁H₂₃N₇O₂S |
| SMILES: | O=S(C1=CC(NC2=NC=CC(N(C3=CC4=NN(C(C)=C4C=C3)C)C)=N2)=CC=C1C)(N)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pazopanib (GW786034) 是多靶点抑制剂，抑制VEGFR1，VEGFR2，VEGFR3，PDGFRβ，c-Kit，FGFR1，c-Fms的IC50分别为10，30，47，84，74，140，146 nM。 |
| IC50和靶点: | [{name:"VEGFR1:10 nM (IC50)"},{name: "VEGFR2:30 nM (IC50)"},{name: "VEGFR3:47 nM (IC50)"},{name: "PDGFRβ:84 nM (IC50)"},{name: "FGFR1:140 nM (IC50)"},{name: "c-Kit:74 nM (IC50)"},{name: "c-Fms:146 nM (IC50)"}] |
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Kumar, R., Knick, V.B., Rudolph, S.K., et al.Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activityMol. Cancer Ther.6(7),2012-2021(2007)
Podar, K., Tonon, G., Satler, M., et al.The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myelomaProc. Natl. Acad. Sci. USA103(5),19478-19483(2006)
