AZD2932
Cat. No.：YN440374
CAS No. ：883986-34-3
规格
价格(RMB)
库存
| 产品名称: | AZD2932 |
| CAS No.: | 883986-34-3 |
| Chemical Name: | 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N-[1-(1-methylethyl)-1H-pyrazol-4-yl]-benzeneacetamide |
| Synonyms: | AZD2932;N-(1-isopropylpyrazol-4-yl)-2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetamide;AZD-2932 |
| 分子量: | 447.49 |
| 分子式: | C₂₄H₂₅N₅O₄ |
| SMILES: | O=C(NC1=CN(C(C)C)N=C1)CC2=CC=C(OC3=C4C=C(OC)C(OC)=CC4=NC=N3)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD2932是有效的多靶点激酶抑制剂，细胞试验中的抑制VEGFR2，PDGFβ，PDGFβ和PDGFβ的IC50值分别为8，4，7，9 nM。 |
| IC50和靶点: | [{name:"VEGFR2:8 nM (IC50)"},{name: "PDGFRβ:4 nM (IC50)"},{name: "FLT3:7 nM (IC50)"},{name: "c-Kit:9 nM (IC50)"}] |
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| Solvent & Solubility: |
Plé, P., Jung, F., Ashton, S., et al.Discovery of AZD2932, a new quinazoline ether inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinasesBioorg. Med. Chem. Lett.22(1),262-266(2012)
