Motesanib
Cat. No.：YN440065
CAS No. ：453562-69-1
规格
价格(RMB)
库存
| 产品名称: | Motesanib |
| CAS No.: | 453562-69-1 |
| Chemical Name: | N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide; AMG 706; |
| Synonyms: | 莫替沙尼; AMG 706; |
| 分子量: | 373.45 |
| 分子式: | C₂₂H₂₃N₅O |
| SMILES: | O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC(NCC4(C)C)=C4C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Motesanib 是一种有效的VEGFR1/2/3的 ATP 竞争性抑制剂，IC50值为 2 nM/3 nM/6 nM，与对Kit的选择性相似，是 PDGFR 和 Ret的 10 倍多。 |
| IC50和靶点: | [{name:"VEGFR1:2 nM (IC50)"},{name: "VEGFR2:3 nM (IC50)"},{name: "VEGFR3:6 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Rosen, L., et al.: J. Clin. Oncol., 25, 2369 (2007), Sherman, S., et al.: New Engl. J. Med., 359, 31 (2008),
