Lenvatinib mesylate
Cat. No.：YN440129
CAS No. ：857890-39-2
规格
价格(RMB)
库存
| 产品名称: | Lenvatinib mesylate |
| CAS No.: | 857890-39-2 |
| Chemical Name: | 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide, monomethanesulfonate |
| Synonyms: | E7080 mesylate |
| 分子量: | 522.96 |
| 分子式: | C₂₂H₂₃ClN₄O₇S |
| SMILES: | O=C(C1=C(OC)C=C2N=CC=C(OC3=CC=C(NC(NC4CC4)=O)C(Cl)=C3)C2=C1)N.OS(=O)(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lenvatinib mesylate (E7080 mesylate)，一种口服，多靶点酪氨酸激酶抑制剂，抑制血管内皮生长因子受体(VEGFR1-3)，成纤维细胞生长因子受体(FGFR1-4)，血小板衍生生长因子受体(PDGFR)，干细胞因子受体(KIT)，转染期间重排(RET)，显示有效抗癌的活性。 |
| IC50和靶点: | [{name:"VEGFR1:22 nM (IC50)"},{name: "VEGFR2:4 nM (IC50)"},{name: "VEGFR3:5.2 nM (IC50)"},{name: "FGFR1:46 nM (IC50)'}, 'FGFR2', 'FGFR3', 'FGFR4', {'PDGFRα:51 nM (IC50)"},{name: "PDGFRβ:39 nM (IC50)"},{name: "c-Kit:100 nM (IC50)'}, 'RET'] |
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Matsui, J., Yamamaoto, Y., Funahashi, Y., et al.E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibitionInt. J. Cancer122(3),664-671(2008)
Matsui, J., Funahashi, Y., Uenaka, T., et al.Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinaseClin. Cancer Res.14(17),5459-5465(2008)
