Motesanib Diphosphate
Cat. No.：YN440066
CAS No. ：857876-30-3
规格
价格(RMB)
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| 产品名称: | Motesanib Diphosphate |
| CAS No.: | 857876-30-3 |
| Chemical Name: | N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide, diphosphate |
| Synonyms: | AMG 706 Diphosphate |
| 分子量: | 569.44 |
| 分子式: | C₂₂H₂₉N₅O₉P₂ |
| SMILES: | O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC(NCC4(C)C)=C4C=C3.O=P(O)(O)O.O=P(O)(O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Motesanib Diphosphate (AMG 706 Diphosphate) 是一种有效的VEGFR1/2/3的 ATP 竞争性抑制剂，IC50值为 2 nM/3 nM/6 nM，与对 Kit 的选择性相似，是 PDGFR 和 Ret 的 10 倍多。 |
| IC50和靶点: | [{name:"VEGFR1:2 nM (IC50)"},{name: "VEGFR2:3 nM (IC50)"},{name: "VEGFR3:6 nM (IC50)"}] |
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Polverino, A., Coxon, A., Starnes, C., et al.AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenograftsCancer Res.66(17),8715-8721(2006)
Davis, M.I., Hunt, J.P., Herrgard, S., et al.Comprehensive analysis of kinase inhibitor selectivityNat. Biotechnol.29(11),1046-1051(2011)
