Gefitinib impurity 1
Cat. No.：YN481057
CAS No. ：675126-26-8
规格
价格(RMB)
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| 产品名称: | Gefitinib impurity 1 |
| CAS No.: | 675126-26-8 |
| Chemical Name: | 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile; 2-Nitro-4-methoxy-5-[3-(morpholin-4-yl)]propoxybenzonitrile; 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile |
| Synonyms: | |
| 分子量: | 321.33 |
| 分子式: | C₁₅H₁₉N₃O₅ |
| SMILES: | N#CC1=CC(OCCCN2CCOCC2)=C(OC)C=C1[N+]([O-])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gefitinib impurity 1 是 Gefitinib 的杂质。Gefitinib 是一种有效的，具有口服活性的选择性EGFR酪氨酸激酶抑制剂，IC50为 33 nM。Gefitinib 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50为 54 nM)，并阻断 EGF 刺激的肿瘤细胞中EGFR自磷酸化。Gefitinib 还可诱导细胞自噬 (autophagy)。Gefitinib 具有抗肿瘤活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Wang, J., et al.: Bioorganic Med. Chem. Lett. 16, 15, 4102-06, (2006)
