Quinolinic acid
Cat. No.：YN360052
| 产品名称: | Quinolinic acid |
| CAS No.: | 89-00-9 |
| Chemical Name: | 2,3-pyridinedicarboxylic acid |
| Synonyms: | 喹啉酸 |
| 分子量: | 167.12 |
| 分子式: | C₇H₅NO₄ |
| SMILES: | O=C(C1=NC=CC=C1C(O)=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Quinolinic acid 是一种内源性的 N-甲基-D-天冬氨酸受体 (NMDA receptor) 激动剂，通过犬尿氨酸途径从 L-色氨酸合成，因此具有调节 N-甲基-D-天冬氨酸神经元损伤和功能障碍的潜力。 |
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Heyes, M.P., Achim, C.L., Wiley, C.A., et al.Human microglia convert L-tryptophan into the neurotoxin quinolinic acidBiochem. J.320(2),595-597(1996)
Stone, T.W., and Perkins, M.N.Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNSEur. J. Pharmacol.72(4),411-412(1981)
Carpenedo, R., Meli, E., Peruginelli, F., et al.Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice culturesJ. Neurochem.82(6),1465-1471(2002)
Lisak, R.P., Nedelkoska, L., Bealmear, B., et al.Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damageExp. Neurol.273,161-167(2015)
Lapin, I.P.Stimulant and convulsive effects of kynurenines injected into brain ventricles in miceJ. Neural. Transm.42(1),37-43(1978)
Cathomas, F., Guetter, K., Seifritz, E., et al.Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorderSci. Rep.11(1),9992(2021)
