Nintedanib esylate
Cat. No.：YN440140
CAS No. ：656247-18-6
规格
价格(RMB)
库存
| 产品名称: | Nintedanib esylate |
| CAS No.: | 656247-18-6 |
| Chemical Name: | (3Z)-2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid, methyl ester, monoethanesulfonate |
| Synonyms: | 乙磺酸尼达尼布; BIBF 1120 esylate |
| 分子量: | 649.76 |
| 分子式: | C₃₃H₃₉N₅O₇S |
| SMILES: | O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)OC.CCS(=O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nintedanib esylate (BIBF 1120 esylate) 是一种有效的VEGFR1/2/3，FGFR1/2/3和PDGFRα/β三重抑制剂，IC50值分别为 34 nM/13 nM/13 nM，69 nM/37 nM/108 nM 和 59 nM/65 nM。 |
| IC50和靶点: | [{name:"VEGFR1:34 nM (IC50)"},{name: "VEGFR2:13 nM (IC50)"},{name: "VEGFR3:13 nM (IC50)"},{name: "FGFR1:69 nM (IC50)"},{name: "FGFR2:37 nM (IC50)"},{name: "FGFR3:108 nM (IC50)"},{name: "PDGFRα:59 nM (IC50)"},{name: "PDGFRβ:65 nM (IC50)"}] |
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| Solvent & Solubility: |
Hilberg, F., Roth, G.J., Krssak, M., et al.BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacyCancer Res.68(12),4774-4782(2008)
