SSR128129E
Cat. No.：YN440333
CAS No. ：848318-25-2
规格
价格(RMB)
库存
| 产品名称: | SSR128129E |
| CAS No.: | 848318-25-2 |
| Chemical Name: | 2-amino-5-[(1-methoxy-2-methyl-3-indolizinyl)carbonyl]-benzoic acid, monosodium salt |
| Synonyms: | SSR |
| 分子量: | 346.31 |
| 分子式: | C₁₈H₁₅N₂NaO₄ |
| SMILES: | O=C(O[Na])C1=CC(C(C2=C(C)C(OC)=C3C=CC=CN23)=O)=CC=C1N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SSR128129E 是口服可用的FGFR变构调节剂， 对FGFR1 的IC50值为1.9 μM。 |
| IC50和靶点: | [{name:"FGFR1:1.9 μM (IC50)'}, 'FGFR2', 'FGFR3', 'FGFR4'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bono, F., De Smet, F., Herbert, C.A., et al.Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric propertiesCancer Cell23(4),477-488(2013)
Dol-Gleizes, F., Delesque-Touchard, N., Marés, A.M., et al.A new synthetic FGF receptor antagonist inhibits arteriosclerosis in a mouse vein graft model and atherosclerosis in apolipoprotein E-deficient micePLoS One8(11),e80027(2013)
Huang, Q.-X., Liang, L.-D., Lan, Z.-C., et al.Effects of ssr128,129e on intimal hyperplasia in autogenous vein grafts of ratsShiyong Yixue Zazhi31(2),188-190(2015)
