ODM-203
Cat. No.：YN440175
CAS No. ：1430723-35-5
规格
价格(RMB)
库存
| 产品名称: | ODM-203 |
| CAS No.: | 1430723-35-5 |
| Chemical Name: | N-[2′,4′-difluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl][1,1′-biphenyl]-3-yl]-cyclopropanesulfonamide |
| Synonyms: | ODM203;ODM 203 |
| 分子量: | 505.54 |
| 分子式: | C₂₆H₂₁F₂N₅O₂S |
| SMILES: | CN(N=C1)C=C1C2=CC=C3C(N=CN3C4=CC(C5=CC=C(F)C=C5F)=CC(NS(C6CC6)(=O)=O)=C4)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ODM-203 是一种有效的FGFR和VEGFR家族的抑制剂，对 FGFR1、FGFR2、FGFR3、FGFR4 的IC50值分别为 11 nM, 16 nM, 6 nM, 35 nM，对 VEGFR1、VEGFR2、VEGFR3 的IC50值分别为 26 nM, 9 nM, 5 nM。ODM-203 具有很强的抗肿瘤活性并诱导抗肿瘤免疫。 |
| IC50和靶点: | [{name:"FGFR1:11 nM (IC50)"},{name: "FGFR2:16 nM (IC50)"},{name: "FGFR3:6 nM (IC50)"},{name: "FGFR4:35 nM (IC50)"},{name: "VEGFR1:26 nM (IC50)"},{name: "VEGFR2:9 nM (IC50)"},{name: "VEGFR3:5 nM (IC50)"},{name: "DDR1:6 nM (IC50)"},{name: "RET:8 nM (IC50)"},{name: "SIK3:23 nM (IC50)"},{name: "PDGFRa:35 nM (IC50)"},{name: "MINK1:41 nM (IC50)"},{name: "MAP4K4:49 nM (IC50)"}] |
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| Solvent & Solubility: |
Holmström, T.H., Moilanen, A.-M., Ikonen, T., et al.ODM-203, a selective inhibitor of FGFR and VEGFR, shows strong antitumor activity, and induces antitumor immunityMol. Cancer Ther.18(1),28-38(2019)
