Erdafitinib
Cat. No.：YN440381
CAS No. ：1346242-81-6
规格
价格(RMB)
库存
| 产品名称: | Erdafitinib |
| CAS No.: | 1346242-81-6 |
| Chemical Name: | N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine |
| Synonyms: | 厄达替尼; JNJ-42756493 |
| 分子量: | 446.54 |
| 分子式: | C₂₅H₃₀N₆O₂ |
| SMILES: | CN1N=CC(C2=NC3=CC(N(C4=CC(OC)=CC(OC)=C4)CCNC(C)C)=CC=C3N=C2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Erdafitinib (JNJ-42756493)是有效的有口服活性的FGFR家族抑制剂；抑制FGFR1-4活性的IC50分别为1.2, 2.5, 3.0和5.7 nM。 |
| IC50和靶点: | [{name:"FGFR1:1.2 nM (IC50)"},{name: "FGFR2:2.5 nM (IC50)"},{name: "FGFR3:3.0 nM (IC50)"},{name: "FGFR4:5.7 nM (IC50)"}] |
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| Solvent & Solubility: |
Perera, T.P.S., Jovcheva, E., Mevellec, L., et al.Discovery and pharmacological characterization of JNJ-42756493 (erdafitinib), a functionally selective small molecule FGFR family inhibitorMol. Cancer Ther.16(6),1010-1020(2017)
