BO-264
Cat. No.：YN440281
CAS No. ：2408648-20-2
规格
价格(RMB)
库存
| 产品名称: | BO-264 |
| CAS No.: | 2408648-20-2 |
| Chemical Name: | N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-4-pyrimidinamine |
| Synonyms: | |
| 分子量: | 353.38 |
| 分子式: | C₁₈H₁₉N₅O₃ |
| SMILES: | COC1=CC=C(C2=NOC(NC3=NC(N4CCOCC4)=NC=C3)=C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BO-264 是一种高效，口服活性的转化酸性卷曲螺旋 3 (TACC3) 抑制剂，IC50为 188 nM，Kd为 1.5 nM。BO-264 特异性阻断FGFR3-TACC3融合蛋白的功能。BO-264 诱导纺锤体检查点依赖的有丝分裂阻滞，DNA 损伤和细胞凋亡 (apoptosis)。BO-264 具有广谱抗肿瘤活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Akbulut, O., Lengerli, D., Saatci, O., et al.A highly potent TACC3 inhibitor as a novel anticancer drug candidateMol. Cancer Ther.19(6),1243-1254(2020)
