JNJ-64619178
Cat. No.：YN310046
CAS No. ：2086772-26-9
| 产品名称: | JNJ-64619178 |
| CAS No.: | 2086772-26-9 |
| Chemical Name: | (1S,2R,3S,5R)-3-[2-(2-amino-3-bromo-7-quinolinyl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1,2-cyclopentanediol |
| Synonyms: | |
| 分子量: | 483.36 |
| 分子式: | C₂₂H₂₃BrN₆O₂ |
| SMILES: | BrC1=C(N)N=C(C=C(CC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-64619178 是一种伪不可逆的、口服活性的、选择性蛋白精氨酸甲基转移酶 5 (PRMT5) 抑制剂，IC50为 0.14 nM。JNJ-64619178 有潜力用于肺癌的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Tao, H., Yan, X., Zhu, K., et al.Discovery of novel PRMT5 inhibitors by virtual screening and biological evaluationsChem. Pharm. Bull. (Tokyo)67(4),382-388(2019)
Wu, T., Millar, H., Gaffney, D., et al.Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer modelsCancer Res.78(13_suppl.),4859(2018)
