Tazemetostat hydrobromide
Cat. No.：YN310246
CAS No. ：1467052-75-0
| 产品名称: | Tazemetostat hydrobromide |
| CAS No.: | 1467052-75-0 |
| Chemical Name: | |
| Synonyms: | EPZ-6438 hydrobromide; E-7438 hydrobromide |
| 分子量: | 653.65 |
| 分子式: | C₃₄H₄₅BrN₄O₄ |
| SMILES: | O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O.[H]Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tazemetostat hydrobromide (EPZ-6438 hydrobromide) 是一种有效，选择性，口服的EZH2抑制剂。Tazemetostat hydrobromide 抑制含有 PRC2 复合体的野生型 EZH2 的活性，Ki值为 2.5±0.5 nM。Tazemetostat hydrobromide 抑制 EZH2，在肽测定和核小体测定中 IC50分别为 11 和 16 nM。Tazemetostat hydrobromide 抑制大鼠 EZH2，IC50为 4 nM。Taz |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
