UNC0642
Cat. No.：YN310254
CAS No. ：1481677-78-4
| 产品名称: | UNC0642 |
| CAS No.: | 1481677-78-4 |
| Chemical Name: | 2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine |
| Synonyms: | UNC 0642,UNC-0642 |
| 分子量: | 546.70 |
| 分子式: | C₂₉H₄₄F₂N₆O₂ |
| SMILES: | CC(N1CCC(NC2=C3C=C(OC)C(OCCCN4CCCC4)=CC3=NC(N5CCC(F)(F)CC5)=N2)CC1)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UNC0642是有效，选择性的赖氨酸甲基转移酶G9a和GLP抑制剂， 抑制G9a的IC50值小于2.5 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Tachibana, M., Sugimoto, K., Nozaki, M., et al.G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesisGenes Dev.16(14),1779-1791(2002)
Wagschal, A., Sutherland, H.G., Woodfine, K., et al.G9a histone methyltransferase contributes to imprinting in the mouse placentaMol. Cell Biol.28(3),1104-1113(2008)
Thomas, L.R., Miyashita, H., Cobb, R.M., et al.Functional analysis of histone methyltransferase G9a in B and T lymphocytesJ. Immunol.181(1),485-493(2008)
Liu, F., Barsyte-Lovejoy, D., Li, F., et al.Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLPJ. Med. Chem.56(21),8931-8942(2013)
