SGC0946
Cat. No.：YN310277
CAS No. ：1561178-17-3
| 产品名称: | SGC0946 |
| CAS No.: | 1561178-17-3 |
| Chemical Name: | 5-bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Synonyms: | SGC0946,SGC 0946 |
| 分子量: | 618.57 |
| 分子式: | C₂₈H₄₀BrN₇O₄ |
| SMILES: | NC1=NC=NC2=C1C(Br)=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CN(CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)C(C)C)O3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SGC0946是组蛋白甲基转移酶DOT1L高效选择性抑制剂，IC50值为0.3nM,有效抑制混合系白血病细胞。 |
| IC50和靶点: | [{name:"DOT1L:.3 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bernt, K.M., and Armstrong, S.A.A role for DOT1L in MLL-rearranged leukemiasEpigenomics3(6),667-670(2011)
Nguyen, A.T., He, J., Taranova, O., et al.Essential role of DOT1L in maintaining normal adult hematopoiesisCell Res.21(9),1370-1373(2011)
Yu, W., Chory, E.J., Wernimont, A.K., et al.Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitorsNat. Commun.3,1288(2012)
