AZ505
Cat. No.：YN310261
CAS No. ：1035227-43-0
| 产品名称: | AZ505 |
| CAS No.: | 1035227-43-0 |
| Chemical Name: | N-cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]-propanamide |
| Synonyms: | AZ505 free base; AZ505; AZ-505; AZ 505; |
| 分子量: | 577.54 |
| 分子式: | C₂₉H₃₈Cl₂N₄O₄ |
| SMILES: | O=C(N(C1CCCCC1)CCNCCC2=C(OCC(N3)=O)C3=C(O)C=C2)CCNCCC4=CC=C(Cl)C(Cl)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZ505 是一种有效的，具有选择性的SMYD2抑制剂，IC50值为 0.12 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ferguson, A.D., Larsen, N.A., Howard, T., et al.Structural basis of substrate methylation and inhibition of SMYD2Structure19(9),1262-1273(2011)
Li, L.X., Fan, L.X., Zhou, J.X., et al.Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney diseaseJ. Clin. Invest.127(7),2751-2764(2017)
