Gambogenic acid
Cat. No.：YN310364
CAS No. ：173932-75-7
| 产品名称: | Gambogenic acid |
| CAS No.: | 173932-75-7 |
| Chemical Name: | (2Z)-4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-2-butenoic acid |
| Synonyms: | 新藤黄酸 |
| 分子量: | 630.77 |
| 分子式: | C₃₈H₄₆O₈ |
| SMILES: | O=C(O)/C(C)=C\C[C@@]1(C2=O)OC(C)(C)[C@]([C@]31OC4=C5C(O)=C(C/C=C(C)/CC/C=C(C)\C)C(O)=C4C/C=C(C)\C)([H])C[C@@]2([H])C=C3C5=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gambogenic acid 是黄藤中的有效成分，具有抗癌活性。Gambogenic acid 为有效的EZH2抑制剂，特异性地与 EZH2-SET 结构域的 Cys668 位点共价结合，诱导 EZH2 泛素化。 |
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Asano, J., Chiba, K., Tada, M., et al.Cytotoxic xanthones from Garcinia hanburyiPhytochemistry41(3),815-820(1996)
Yan, F., Wang, M., Li, J., et al.Gambogenic acid induced mitochondrial-dependent apoptosis and referred to phospho-Erk1/2 and phospho-p38 MAPK in human hepatoma HepG2 cellsEnviron. Toxicol. Pharmacol.33(2),181-190(2012)
Li, F., Wang, Y., and Yan, Y.Gambogenic acid induces cell growth inhibition, cell cycle arrest and metastasis inhibition in choroidal melanoma in a dose-dependent mannerExp. Ther. Med.13(5),2456-2462(2017)
Wang, B., Yuan, T., Zha, L., et al.Oral delivery of gambogenic acid by functional polydopamine nanoparticles for targeted tumor therapyMol. Pharm.18(3),1470-1479(2021)
