LLY-507
Cat. No.：YN310317
CAS No. ：1793053-37-8
| 产品名称: | LLY-507 |
| CAS No.: | 1793053-37-8 |
| Chemical Name: | 5-cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]-[1,1'-biphenyl]-3-carboxamide |
| Synonyms: | LLY 507,LLY507 |
| 分子量: | 574.76 |
| 分子式: | C₃₆H₄₂N₆O |
| SMILES: | O=C(C1=CC(C2=CC=CC=C2N3CCN(CCN4C=C(C)C5=C4C=CC=C5)CC3)=CC(C#N)=C1)NCCCN6CCCC6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LLY-507是有效和选择性的蛋白-赖氨酸甲基转移酶SMYD2抑制剂，IC50为15 nM。 |
| IC50和靶点: | [{name:"SMYD2:<15 nM (IC50)"}] |
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| Solvent & Solubility: |
Abu-Farha, M., Lambert, J.-P., Al-Madhoun, A.S., et al.The tale of two domains: Proteomics and genomics analysis of SMYD2, a new histone methyltransferaseMol. Cell Proteomics7(3),560-572(2008)
Brown, M.A., Sims, R.J., III, Gottlieb, P.D., et al.Identification and characterization of Smyd2: A split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complexMol. Cancer5,26(2006)
Lee, K., Lee, J.H., Boovanahalli, S.K., et al.(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitorsJ. Med. Chem.50,1675-1684(2007)
