3-Deazaneplanocin A hydrochloride
Cat. No.：YN310153
CAS No. ：120964-45-6
| 产品名称: | 3-Deazaneplanocin A hydrochloride |
| CAS No.: | 120964-45-6 |
| Chemical Name: | 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol, monohydrochloride |
| Synonyms: | 3-去氮腺嘌呤A盐酸盐; DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride |
| 分子量: | 298.73 |
| 分子式: | C₁₂H₁₅ClN₄O₃ |
| SMILES: | O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C2C=CN=C3N.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3-Deazaneplanocin A hydrochloride (DZNep hydrochloride) 是一种有效的组蛋白甲基转移酶 (EZH2) 抑制剂。3-Deazaneplanocin A hydrochloride 是一种有效的 S-腺苷同型半胱氨酸水解酶 (AHCY) 抑制剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Simon, J.A., and Lange, C.A.Roles of the EZH2 histone methyltransferase in cancer epigeneticsMutat. Res.647(1-2),21-29(2008)
Tseng, C.K.H., Marquez, V.E., Fuller, R.W., et al.Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activitiesJ. Med. Chem.32(7),1442-1446(1989)
Fiskus, W., Wang, Y., Sreekumar, A., et al.Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cellsBlood114(13),2733-2743(2009)
Bissinger, E.M., Heinke, R., Sippl, W., et al.Targeting epigenetic modifiers: Inhibitors of histone methyltransferasesMed. Chem. Commun.1(2),(2010)
